(3α,5β,7β)-3,7-Bis(Formyloxy)-24-norcholane-23-nitrile

Chemical Name:(3α,5β,7β)-3,7-Bis(Formyloxy)-24-norcholane-23-nitrile
Synonyms:rac-(3R,5S,7S,8R,9S,10S,13R,14S,17R)-17-((R)-1-Cyanopropan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diyl diformate
CAS Number:118316-07-7
Molecular Formula:C₂₅H₃₇NO₄
Molecular Weight:415.57
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(3α,5β,7β)-3,7-Bis(Formyloxy)-24-norcholane-23-nitrile is an intermediate in the synthesis of 24-Nor Ursodeoxycholic Acid (N865300), a Ursodeoxycholic Acid (U850000) derivative. 24-norUrsodeoxycholic acid is superior to Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.
References:Seedorf, U., et al.: J. Biol. Chem., 269, 21277 (1994), Stolowich, N., et al.: Biochemistry, 36, 1719 (1997),
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