CAS:282101-98-8|2-Chloro-5-nitropyrimidin-4-ol

Catalogue Number:C371411
Chemical Name:2-Chloro-5-nitropyrimidin-4-ol
Synonyms:2-Chloro-5-nitro-4(3H)-pyrimidinone; 2-Chloro-5-nitro-4(1H)-pyrimidinone;
CAS Number:282101-98-8
Molecular Formula:C₄H₂ClN₃O₃
Molecular Weight:175.53
Category:Building Blocks; Miscellaneous;
Applications:2-Chloro-5-nitropyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).
References:Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)
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