CAS:1900716-17-7|5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine

Catalogue Number:C376016
Chemical Name:5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine
CAS Number:1900716-17-7
Molecular Formula:C₉H₇ClN₄
Appearance:White Solid
Molecular Weight:206.63
Storage:-20°C
Solubility:Acetone
Category:Building Blocks; Miscellaneous;
Applications:5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.
References:Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),
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