Cyclosporin AM 4N-D3

Chemical Name:Cyclosporin AM 4N-D3
Synonyms:9-L-Leucinecyclosporin A-D3; 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-D3 Cyclic Peptide Deriv.; AM 4N-D3; Cyclosporin A-D3 Metabolite 21; M 21-D3; OL 21-D3; [Leu4]cyclosporin-D3
Alternate CAS #:Unlabelled: 89270-23-5
Molecular Formula:C₆₁H₁₀₆D₃N₁₁O₁₂
Molecular Weight:1191.6
Category:Standards; Phenethylamines/Amphetamines;
Applications:Cyclosporin AM 4N-D3 is a labelled derivative of Cyclosporin AM 4N (C989410). Cyclosporin AM 4N is a metabolite of Cyclosporin A (C988900), a hydrophobic cyclic undecapeptide that is used as a potent immunosuppressive agent that has application in human organ transplantation. Cyclosporin A works by inhibiting subsets of T lymphocytes to facilitate organ transplantation.
References:Brooks, C., et al.: Clin. Chem., 39, 457 (1993); Colombani, P., et al.: Science, 228, 337 (1985);Krönke, M., et al.: Proc. Nat. Acad. Sci., 81, 5214 (1984); Liu, J., et al.: Cell, 66, 807 (1991); Serino, F., et al.: Mol. Cell. Biochem., 122, 101 (1993)
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