CAS:1189923-43-0|1-(3-Chlorophenyl)piperazine-d8

Catalogue Number:C379592
Chemical Name:1-(3-Chlorophenyl)piperazine-d8
Synonyms:1-(m-Chlorophenyl)piperazine-d8; 4-(3-Chlorophenyl)piperazine-d8;
CAS Number:1189923-43-0
Alternate CAS #
unlabelled: 6640-24-0
Molecular Formula:C₁₀H₅D₈ClN₂
Appearance:Colourless to Yellow Oil to Solid
Molecular Weight:204.73
Storage:4°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Isotopic Labeled Analogues; Stimulant; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
References:Melzacka, M., et al.: Pol. J. Pharmacol Pharm., 32, 551 (1980), Fong, M.H., et al.: J. Pharm. Pharmacol., 34, 674 (1982), Fiorella, D., et al.: Psychopharmacology, 119, 220 (1995), Maes, M., et al.: J. Clin. Psychopharmacol., 17, 358 (1997), Bo Wen, et al.: Drug Metab. Dispos., 36, 841 (2008),
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