6,7-Dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-4-quinazolinamine

Chemical Name:6,7-Dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-4-quinazolinamine
Synonyms:BAY-293
CAS Number:2244904-70-7
Molecular Formula:C₂₅H₂₈N₄O₂S
Molecular Weight:448.58
Category:Research Tools; Standards; Chiral Molecules; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:6,7-Dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-4-quinazolinamine is an effective and selective inhibitor of SOS1, blocking RAS activation via disruption of the KRAS-SOS1 interaction without significantly targeting the EGFR receptor. Thus, it has potential use in treatment of hyperproliferative disorders.
References:Hillig, R., et al. Proc. Natl. Acad. Sci. U.S.A., 116, 2551 (2019); Wortmann, L., et al.: PCT Int. Appl. (2018), WO 2018172250 A1
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