CAS:201594-84-5|(S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine

Catalogue Number:C380335
Chemical Name:(S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine
Synonyms:2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine
CAS Number:201594-84-5
Molecular Formula:C₁₇H₁₉ClN₂O
Appearance:Colourless to Dark Yellow Oil to Thick Oil
Molecular Weight:302.8
Storage:4°C
Solubility:Chloroform (Soluble), Methanol (Sparingly)
Category:Building Blocks; Chiral Molecules;
Applications:(S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine is used as a reagent to prepare optically active 4-[(4-chlorophenyl-2-pyridyl)methoxy]piperidine, a compound that is used as an intermediate in the synthesis of antihistamines and antiallergy agents. (S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine is also an intermediate of Bepotastine besylate (B317000), a non-sedating H1-antagonist that has anti-inflammatory activity.
References:Kita, J. Preparation of Optically Active 4-[(4-Chlorophenyl-2-pyridyl)methoxy]piperidine As A Material For Antihistamines and Antiallergy Agents. Jpn. Kokai Tokkyo Koho JP 10182635. Jul 7, 1998; Ohashi, R., et al.: Drug Metab. Disp., 34, 793 (2006)
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