Propanamino-Osimertinib Dimer

Propanamino-Osimertinib Dimer

Chemical Name:Propanamino-Osimertinib Dimer
Synonyms:N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanamide; 3-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanamino Osimertinib
Molecular Formula:C₅₃H₆₄N₁₄O₃
Molecular Weight:945.17
Applications:3-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanamino Osimertinib is an impurity of AZD 9291(A808075) which is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).
References:Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);
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