CAS:402855-07-6|(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine

Catalogue Number:C430335
Chemical Name:(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
Synonyms:Afatinib Impurity A
CAS Number:402855-07-6
Molecular Formula:C₁₈H₁₄ClFN₄O₄
Molecular Weight:404.78
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine is an intermediate used in the preparation of afatinib ant it’s impurities. Afatinib(A355300) is an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References:Yu, Y., et al.: From Faming Zhuanli Shenqing (2019), CN 110590682 A 20191220.; Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)
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