Docetaxal-d9

Chemical Name:Docetaxal-d9
Synonyms:(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester-d9; 10-Acetyldocetaxel-d9; 10-Acetyltaxotere-d9; PNU 101383-d9;
Alternate CAS #:Unlabelled:125354-16-7
Molecular Formula:C₄₅H₄₆D₉NO₁₅
Molecular Weight:858.97
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Docetaxal-d9, is the labeled analogue of Docetaxal (D494565), which is a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.
References:Zhu, Q.Q., et al.: J. Med. Chem., 40, 4319 (1997); Burkhart, C.A., et al.: Cancer. Res., 54, 5779 (1994); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)
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