Emtricitabine Dephenyl Tenofovir Alafenamide

Emtricitabine Dephenyl Tenofovir Alafenamide

Chemical Name:Emtricitabine Dephenyl Tenofovir Alafenamide
Synonyms:P-((((2R)-1-(6-((((5-Fluoro-1-((2S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-((S)-1-isopropoxy-1-oxopropan-2-yl)phosphonamidic acid
Molecular Formula:C₂₄H₃₅FN₉O₈PS
Molecular Weight:659.63
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Emtricitabine Dephenyl Tenofovir Alafenamide is a mixed dimer of Emtricitabine(E525000) which is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500). and Tenofovir (T018500) which is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References:FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);
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