CAS:82009-34-5|Cilastatin

Catalogue Number:C441100
Chemical Name:Cilastatin
Synonyms:(2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid; MK-791;
CAS Number:82009-34-5
Molecular Formula:C₁₆H₂₆N₂O₅S
Appearance:White to Light Brown Solid
Melting Point:>144ºC (dec.)
Molecular Weight:358.45
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Cilastatin prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. It is an antibacterial adjunct.
References:Finlay, K.R., et al.: Invest. Ophthalmol. Visual Sci., 24, 1147 (1983); Norrby, S.R., et al.: Antimicrob. Agents Chemother., 23, 300 (1983); Washburn, D.E., et al.: J. Antimicrob. Chemother., 12, 39 (1983);
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