CAS:1163-36-6|Clemizole Hydrochloride

Catalogue Number:C559740
Chemical Name:Clemizole Hydrochloride
Synonyms:1-(4-Chlorobenzyl)-2-(pyrrolidinylmethyl)-1,3-benzimidazole Hydrochloride; 1-p-Chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole Hydrochloride;
CAS Number:1163-36-6
Alternate CAS #
Free Base 442-52-4
Molecular Formula:C₁₉H₂₀ClN₃ • (HCl)
Appearance:White to Off-White Solid
Melting Point:>232°C (dec.)
Molecular Weight:325.84+ (36.46)
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;
Applications:Clemizole Hydrochloride inhibits Hepatitis C RNA replication in cell culture through the suppression of the binding between the nonstructural protein 4B and the viral RNA genome with little toxicity for the host cell. Clemizole Hydrochloride is also a potent inhibitor of transient receptor potential channel TRPC5.
References:Einav, S., et al.: Nat. Biotechnol., 26, 1019 (2008); Richter, J. M., et al.: Mol. Pharmacol., 86, 514 (2014)
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