CAS:1643330-62-4|5-Chloropentanamide Apixaban

Catalogue Number:C583755
Chemical Name:5-Chloropentanamide Apixaban
Synonyms:Apixaban Impurity 3; 5-Chloro-N-(4-(3-morpholino-2-oxo-5,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide
CAS Number:1643330-62-4
Molecular Formula:C₂₀H₂₆ClN₃O₃
Appearance:Light Brown to Brown Solid
Melting Point:>152°C
Molecular Weight:391.9
Storage:-20°C
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-Chloropentanamide Apixaban is an impurity of Apixaban (503612-47-3 #CAS), which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References:Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);
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