CAS:13551-86-5|1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole

Catalogue Number:C592035
Chemical Name:1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole
Synonyms:1-Chloro-3-(2-nitroimidazol-1-yl)propan-2-ol; Ro 07-0269; α-(Chloromethyl)-2-nitro-1H-imidazole-1-ethanol
CAS Number:13551-86-5
Molecular Formula:C₆H₈ClN₃O₃
Molecular Weight:205.6
Category:Building Blocks; Miscellaneous;
Applications:1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole is an intermediate in the synthesis of 1-(2,3-Epoxypropyl)-2-nitroimidazole (B592583) which is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.
References:Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)
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