CAS:168555-66-6|Combretastatin A4 Phosphate Disodium Salt

Catalogue Number:C643025
Chemical Name:Combretastatin A4 Phosphate Disodium Salt
Synonyms:2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 1-(Dihydrogen phosphate) Sodium Salt; CA 4P;
CAS Number:168555-66-6
Alternate CAS #
Free Acid: 222030-63-9
Molecular Formula:C₁₈H₁₉Na₂O₈P
Appearance:White to Off-White Solid
Melting Point:>187°C (dec.)
Molecular Weight:440.29
Storage:4°C
Solubility:Methanol (Slightly), Water (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Phosphorylated Combretastatin, a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.
References:Hamel, E., et al.: Biochem. Pharmacol., 32, 3863 (1983), Chaplin, D.J., et al.: Br. J. Cancer, 74, S86, (1996)
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