12(S)-Hydroxy (5Z,8Z,10E,14Z)-Eicosatetraenoic Acid

Chemical Name:12(S)-Hydroxy (5Z,8Z,10E,14Z)-Eicosatetraenoic Acid
Synonyms:[S-(E,Z,Z,Z)]-12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 12-HETE; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 12-Hydroxyeicosatetraenoic Acid; 12-L-Hydroxy-5,8,10,14-eicosatetraenoic Acid;
CAS Number:54397-83-0
Molecular Formula:C₂₀H₃₂O₃
Molecular Weight:320.47
Category:Standards; Lipids/Fatty Acids, Glycerol Derivatives;
Applications:A fatty acid metabolite of arachidonic acid (A765000). Potential biomarker for asthma monitoring and diagnosis. Stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Used in the study of mechanisms controlling cell cycle arrest and induction of apoptosis in prostate cancer cells via 12-lipoxygenase inhibition..
References:Nording, M.L. et al.: IEEE Sensors J., 10, 123 (2010); Pidgeon, G.P. et al.: Canc. Res., 62, 2721 (2002); Honn, K.V. et al.: Exp. Cell Res., 214, 120 (1994); Feldstein, A.E. et al.: J. Lipid Res., 51, 3046 (2010);
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