CAS:2042519-10-6|4-​[3-​[4-​Cyano-​3-​(trifluoromethyl)​phenyl]​-​5,​5-​dimethyl-​4-​oxo-​2-​thioxo-​1-​imidazolidinyl]​-​2-​fluoro-​N-​[6-​(hydroxyamino)​-​6-​oxohexyl]​benzamide

Catalogue Number:C778070
Chemical Name:4-​[3-​[4-​Cyano-​3-​(trifluoromethyl)​phenyl]​-​5,​5-​dimethyl-​4-​oxo-​2-​thioxo-​1-​imidazolidinyl]​-​2-​fluoro-​N-​[6-​(hydroxyamino)​-​6-​oxohexyl]​benzamide
Synonyms:4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-(6-(hydroxyamino)-6-oxohexyl)benzamide
CAS Number:2042519-10-6
Molecular Formula:C₂₆H₂₅F₄N₅O₄S
Molecular Weight:579.57
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-​[3-​[4-​Cyano-​3-​(trifluoromethyl)​phenyl]​-​5,​5-​dimethyl-​4-​oxo-​2-​thioxo-​1-​imidazolidinyl]​-​2-​fluoro-​N-​[6-​(hydroxyamino)​-​6-​oxohexyl]​benzamide is used for targeting prostate cancer, because of dual activity as androgen receptor antagonists and HDAC6 inhibitors.
References:Jadhavar, P. S., et al.: Bioorg. Med. Chem. Lett. 26, 5222 (2016)
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