CAS:843-93-6|CP-10447

Catalogue Number:C781200
Chemical Name:CP-10447
Synonyms:3-(4-Bromo-2-methylphenyl)-2-methyl-4(3H)-quinazolinone; CP 10447; 3-(4-Bromo-o-tolyl)-2-methyl-4(3H)-quinazolinone;
CAS Number:843-93-6
Molecular Formula:C₁₆H₁₃BrN₂O
Appearance:White to Off-White Solid
Melting Point:148-150°C
Molecular Weight:329.19
Storage:4°C
Solubility:Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:CP-10447 is an inhibitor apolipoprotein B (apoB) and triglyceride secretion in human hepatoma cells (HepG2) by inhibiting MTP activity and stimulating the early ER degradation of apoB. It is useful tool for further study of the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly.
References:Haghpassand, M. et al.: J. Lipid. Res., 37, 1468 (1996); Pan, M. et al.: J. Biol. chem., 275, 27399 (2000);
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