Indicine N-Oxide-D7

Chemical Name:Indicine N-Oxide-D7
Synonyms:(2R,3S)-2,3-Dihydroxy-2-(1-methylethyl)butanoic Acid [(1R,7aS)-2,3,5,7a-Tetrahydro-1-hydroxy-4-oxido-1H-pyrrolizin-7-yl]methyl Ester-D7; [1R-[1α,7(2R*,3S*),7aβ]]-2,3-Dihydroxy-2-(1-methylethyl)butanoic Acid (2,3,5,7a-Tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl Ester N-Oxide-D7; (+)-Indicine N-oxide-D7; NSC 132319-D7
Alternate CAS #:Unlabelled: 41708-76-3
Molecular Formula:C₁₅H₁₈D₇NO₆
Molecular Weight:322.41
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Indicine N-oxide-D7 is a labelled analogue of Indicine N-oxide (I521105). Indicine N-oxide is a pyrrolizidine alkaloid that is isolated from Heliotropium indicum, one of the most widely used herbs in India. Indicine N-oxide exhibits antitumour and antimitotic activity in humans, and has subsequently undergone Phase I & II trials in adults and children with leukemia and solid tumours.
References:Kovach, J., et al.: Cancer Res., 39, 4540 (1979); Powis, G., et al.: Cancer Res., 39, 3564 (1979); Whitehead, V., et al.: Cancer Chemo. Pharma., 26, 377 (1990)
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