CAS:52378-40-2|N-Cyano-N’-[2-[(4-methyl-5-imidazolyl)methylthio]ethyl]-S-methylisothiourea

Catalogue Number:C981850
Chemical Name:N-Cyano-N’-[2-[(4-methyl-5-imidazolyl)methylthio]ethyl]-S-methylisothiourea
Synonyms:N-Cyano-N’-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]carbamimidothioic Acid Methyl Ester;
Impurity:Cimetidine EP Impurity A
CAS Number:52378-40-2
Molecular Formula:C₁₀H₁₅N₅S₂
Appearance:Pale Yellow to Yellow Solid
Melting Point:140-142°C
Molecular Weight:269.39
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Light Sensitive
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-Cyano-N’-[2-[(4-methyl-5-imidazolyl)methylthio]ethyl]-S-methylisothiourea (Cimetidine EP Impurity A) is a Cimetidine (C441650) related impurity. Cimetidine (C441650), a competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output. Also used in the preparation of histamine H2 receptor antagonists.
References:Brimblecombe, R.W., et al.: J. Int. Med. Res., 3, 86 (1975), Ching, T. et al.: Eur. j. Pharm. Mol. Pharm. Sec., 268, 89 (1994);
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