(R)-Irofulven

Chemical Name:(R)-Irofulven
Synonyms:(6’R)-6′-Hydroxy-3′-(hydroxymethyl)-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-[5H]inden]-7′(6’H)-one; (-)-(Hydroxymethyl)acylfulvene; (-)-Irofulven; HMAF; MGI 114; NSC 683863;
CAS Number:158440-71-2
Molecular Formula:C₁₅H₁₈O₃
Appearance:Orange Solid
Molecular Weight:246.31
Storage:-20°C, Inert atmosphere
Solubility:Chloroform (Slightly), Ethyl Acetate (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Semi-synrhetic antitumor agent derived from Illudin S. Inhibits DNA synthesis and induces apoptosis in tumor cells. Antineoplastic.
References:Woynarowski, J.M., et al.: Biochem. Pharmacol., 54, 1181 (1997), Alexandre, J., et al.: Clin. Cancer Res., 10, 3377 (2004), Senzer, N., et al.: Am. J. Clin. Oncol., 28, 36 (2005),
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