CAS:1821033-10-6|2-Cyano-N-(3,5-dichloro-4-methoxyphenyl)-acetamide

Catalogue Number:C989438
Chemical Name:2-Cyano-N-(3,5-dichloro-4-methoxyphenyl)-acetamide
CAS Number:1821033-10-6
Molecular Formula:C₁₀H₈Cl₂N₂O₂
Molecular Weight:259.09
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-Cyano-N-(3,5-dichloro-4-methoxyphenyl)-acetamide is the impurity of the drug Bosutinib (B676095), which is a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. It is related to 4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile (D435380).
References:Bjorge, J., et al.: J. Biol. Chem., 275, 41439 (2000); Frame, M., et al.: Biochim. Biophys. Acta, 1602, 114 (2002); Frame, M., et al.: J. Cell Sci., 117, 989 (2004); Ishizawar, R., et al.: Cancer Cell, 6, 209 (2004); Diaz, N., et al.: Clin. Cancer Res., 12, 20 (2006);
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