CAS:1941177-45-2|4-​[6-​[(8-​Cyclopentyl-​6-​ethenyl-​7,​8-​dihydro-​5-​methyl-​7-​oxopyrido[2,​3-​d]​pyrimidin-​2-​yl)​amino]​-​3-​pyridinyl]​-1-​Piperazinecarboxylic Acid 1,​1-​Dimethylethyl Ester

Catalogue Number:C992563
Chemical Name:4-​[6-​[(8-​Cyclopentyl-​6-​ethenyl-​7,​8-​dihydro-​5-​methyl-​7-​oxopyrido[2,​3-​d]​pyrimidin-​2-​yl)​amino]​-​3-​pyridinyl]​-1-​Piperazinecarboxylic Acid 1,​1-​Dimethylethyl Ester
CAS Number:1941177-45-2
Molecular Formula:C₂₉H₃₇N₇O₃
Appearance:Light Yellow to Dark Beige Solid
Melting Point:>220°C (dec.)
Molecular Weight:531.66
Storage:-20°C
Solubility:Dichloromethane (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)
Stability
Light Sensitive
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-​[6-​[(8-​Cyclopentyl-​6-​ethenyl-​7,​8-​dihydro-​5-​methyl-​7-​oxopyrido[2,​3-​d]​pyrimidin-​2-​yl)​amino]​-​3-​pyridinyl]​-1-​Piperazinecarboxylic Acid 1,​1-​Dimethylethyl Ester is an impurity of Palbociclib (P139900) an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References:Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);
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