CAS:204206-07-5|(2E)-2-[1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]-acetic Acid Ethyl Ester Hydrochloride

Catalogue Number:C997778
Chemical Name:(2E)-2-[1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]-acetic Acid Ethyl Ester Hydrochloride
Synonyms:(E)-[1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]-acetic Acid Ethyl Ester Hydrochloride
CAS Number:204206-07-5
Alternate CAS #
Free Base: 239466-84-3
Molecular Formula:C₂₀H₂₄FNO₃S • (HCl)
Molecular Weight:377.47 + (36.46)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2E)-2-[1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]-acetic Acid Ethyl Ester Hydrochloride is an intermediate in the synthesis of trans R-138727, (Prasugrel Metabolite) (R070195), which is the active metabolite of Prasugrel (P701150); inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: influence of other blood cells, calcium, and aspirin.
References:Ekins, S., et al.: J. Pharmacol. Exp. Ther., 286, 1253 (1998); Lamba, V., et al.: J. Pharmacol Exp. Ther., 307, 906 (2003); Yoneda, K., et al.: Br. J. Pharmacol., 142, 551 (2004); Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 47, 377 (2006); Rehmel, J., et al.: Drug Metab. Dispos., 34, 600 (2006)
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