CAS:173075-23-5|(2E)-2-Cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide

CAS:173075-23-5|(2E)-2-Cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide

Catalogue Number:C999080
Chemical Name:(2E)-2-Cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide
Synonyms:AG 775
CAS Number:173075-23-5
Molecular Formula:C₁₀H₈N₂O₄
Molecular Weight:220.18
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2E)-2-Cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide, is an impurity of Entacapone (E558500), E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References:Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992); Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992); Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993);
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