CAS:157239-71-9|(1R,​2R,​3S,​5S)​- 3-​(3,​4-​Dichlorophenyl)​-​8-​methyl-8-​azabicyclo[3.2.1]​octane-​2-​carboxylic Acid Methyl Ester

Catalogue Number:D157240
Chemical Name:(1R,​2R,​3S,​5S)​- 3-​(3,​4-​Dichlorophenyl)​-​8-​methyl-8-​azabicyclo[3.2.1]​octane-​2-​carboxylic Acid Methyl Ester
Synonyms:[1R-(2-endo,3-exo)]-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester
CAS Number:157239-71-9
Molecular Formula:C₁₆H₁₉Cl₂NO₂
Molecular Weight:328.23
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(1R,​2R,​3S,​5S)​- 3-​(3,​4-​Dichlorophenyl)​-​8-​methyl-8-​azabicyclo[3.2.1]​octane-​2-​carboxylic Acid Methyl Ester is an intermediate in the synthesis of Tesofensine (T136500), which is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.
References:Hansen, H., et al.: Pharmacology, Biochemistry and Behavior, 110, 265 (2013);
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