CAS:173667-94-2|(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-methanol

Catalogue Number:D173665
Chemical Name:(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-methanol
Synonyms:[1R-(2-endo,3-exo)]-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-methanol
CAS Number:173667-94-2
Molecular Formula:C₁₅H₁₉Cl₂NO
Molecular Weight:300.22
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-methanol is an intermediate in the synthesis of Tesofensine (T136500), which is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.
References:Hansen, H., et al.: Pharmacology, Biochemistry and Behavior, 110, 265 (2013);
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