CAS:69819-86-9|Darinaparsin

Catalogue Number:D193425
Chemical Name:Darinaparsin
Synonyms:N-[S-(Dimethylarsino)-N-L-γ-glutamyl-L-cysteinyl]-glycine; Dimethylarsinic Glutathione; ZIO 101; Zinapar; L-γ-Glutamyl-S-(dimethylarsino)-L-cysteinyl-glycine
CAS Number:69819-86-9
Molecular Formula:C₁₂H₂₂AsN₃O₆S
Appearance:White to Off-White Solid
Melting Point:>188°C (dec.)
Molecular Weight:411.31
Storage:-20°C
Solubility:Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Heated, Sonicated)
Category:Research Tools; Amino Acids; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Darinaparsin is an arsenic cytotoxin that has been used in pharmacological activities to evaluate the effect on survival an radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models. Darinaparsin has significant and preferential cytotoxic and radiosensitizing effects on solid tumors as compared with normal cells.  Darinaparsin may therefore increase the therapeutic index of radiation therapy and has near term translational potential.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Tian, J., et al.: Clin. Cancer Res., 18, 3366 (2012); Ning, S., et al.: Int. J. Radiat. Oncol. Biol. Phys., 65, 493 (2006);
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