4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methyl-d3-picolinamide Hydrochloride

Chemical Name:4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methyl-d3-picolinamide Hydrochloride
Molecular Formula:C₁₉H₁₅D₃ClFN₄O₃
Molecular Weight:407.84
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methyl-d3-picolinamide Hydrochloride is the labeled analogue of 4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methylpicolinamide Hydrochloride (A609745), an impurity of Regorafenib (R143000), which inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
References:Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)
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