CAS:152242-11-0|N-Deacetyl-1,2,3,10-demethyl Colchicine Hydrobromide

Catalogue Number:D198195
Chemical Name:N-Deacetyl-1,2,3,10-demethyl Colchicine Hydrobromide
Synonyms:(S)-7-Amino-6,7-dihydro-1,2,3,9-tetrahydroxy-,benzo[a]heptalen-10(5H)-one, Hydrobromide
CAS Number:152242-11-0
Alternate CAS #
134568-35-7
Molecular Formula:C₁₆H₁₅NO₅ • H Br
Molecular Weight:301.29 + 80.91
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-Deacetyl-1,2,3,10-demethyl Colchicine Hydrobromide is a derivative of Colchicine (C640000) an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References:Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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