D-2-Amino-5-phosphonopentanoic Acid

Chemical Name:D-2-Amino-5-phosphonopentanoic Acid
Synonyms:5-Phosphono-D-norvaline; (-)-2-Amino-5-phosphonopentanoic Acid; (-)-2-Amino-5-phosphonovaleric Acid; (R)-2-Amino-5-phosphonopentanoic Acid; (R)-AP-5; D-(-)-2-Amino-5-phosphonopentanoic Acid; D-2-Amino-5-phosphonopentanoic Acid; D-2-Amino-5-phosphonovaleric Acid; D-AP-5; D-Aminophosphonovaleric Acid
CAS Number:79055-68-8
Molecular Formula:C₅H₁₂NO₅P
Appearance:White to Off-White Solid
Molecular Weight:197.13
Storage:-20°C
Solubility:Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:D-2-Amino-5-phosphonopentanoic Acid is the more active form of AP 5 and is a N-methyl-D-aspartate (NMDA) receptor antagonist that competitively inhibits the glutamate binding site of NMDA receptors.
References:Davies, J., et al.: Brain Res., 235, 378 (1982); Evans, R.H., et al.: Br. J. Pharmacol., 75, 65 (1982)
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