CAS:160094-11-1|5-O-Demethyl-5-O-[(2-propen-1-yloxy)carbonyl]avermectin A1a (>80%)

Catalogue Number:D228880
Chemical Name:5-O-Demethyl-5-O-[(2-propen-1-yloxy)carbonyl]avermectin A1a (>80%)
Synonyms:5-O-Demethyl-5-O-[(2-propenyloxy)carbonyl]-avermectin A1a;
CAS Number:160094-11-1
Molecular Formula:C₅₂H₇₆O₁₆
Appearance:Pale Green Solid
Melting Point:>124°C (dec.)
Molecular Weight:957.15
Storage:-20°C, Inert atmosphere, Light sensitive
Solubility:Chloroform (Slightly, Sonicated), Methanol (Slightly)
Category:Building Blocks; Chiral Molecules; Miscellaneous;
Applications:5-O-Demethyl-5-O-[(2-propen-1-yloxy)carbonyl]avermectin A1a is an intermediate used in the synthesis of Emamectin-D3 (E520402), which is deuterium labeled emamectin, a soluble derivative of avermectin and used as parasiticide and insecticide. Emamectin activates glutamate-gated chloride channels.
References:Xu X., et al.: Biochem Biophys Res Commun 473, 795 (2016); Lumaret, J. P., et al.: Curr Pharm Biotechnol. 13, 1004 (2012)
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