CAS:1217668-72-8|Demecolcine-d3

Catalogue Number:D230787
Chemical Name:Demecolcine-d3
Synonyms:(7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one-d3; Deacetylmethylcolchicine-d3; Colchamin-d3; NSC 3096-d3; Omain-d3; Omaine-d3; Reichstein’s F-d3;N-Desacetyl-N-methylcolchicine-d3; Colcemid-d3;
CAS Number:1217668-72-8
Alternate CAS #
unlabelled: 477-30-5
Molecular Formula:C₂₁H₂₂D₃NO₅
Appearance:Faintly Yellow Crystalline Powder
Melting Point:73-75°C
Molecular Weight:374.45
Solubility:Dichlormethane, DMSO, Methanol
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References:Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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