CAS:1417576-00-1|Desethyl Azilsartan Medoxomil

Catalogue Number:D289258
Chemical Name:Desethyl Azilsartan Medoxomil
Synonyms:3-[[2′-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2,3-dihydro-2-oxo-1H-benzimidazole-4-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester
CAS Number:1417576-00-1
Molecular Formula:C₂₈H₂₀N₄O₈
Appearance:White to Off-White Solid
Melting Point:144 – 154°C
Molecular Weight:540.48
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly, Heated)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Desethyl Azilsartan Medoxomil is an impurity from the synthesis of Azilsartan Medoxomil (A926910). Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).
References:Radl, S., et al.: Org. Process. Res. Dev., 17), 77-86 (2013); Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)
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