CAS:1217201-17-6|A350619 Hydrochloride

Catalogue Number:A101010
Chemical Name:A350619 Hydrochloride
Synonyms:3-[2-[(4-Chlorophenyl)thio]phenyl]-N-[4-(dimethylamino)butyl]-2-propenamide, , Hydrochloride;
CAS Number:1217201-17-6
Molecular Formula:C₂₁H₂₆Cl₂N₂OS
Molecular Weight:425.41
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A350619 Hydrochloride is an activator of guanylyl cyclase (sGC). It activates basal sGC and synergistically activates sGC in the presence of NO. Acting as an sGC stimulator, it may be more effective than PDE5 inhibitors in the treatment of ED.
References:Gur, S., et al.: Curr. Pharm. Des., 16, 1619 (2010); Nandhakumar, J., et al.: J. Neurol. Neurophysiol., 2, 1000110 (2011); Miller, L., et al.: Life Sci., 72, 1015 (2003);
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