CAS:220519-06-2|A 37203

Catalogue Number:A101030
Chemical Name:A 37203
Synonyms:Lu 201640; 2-[[3-[4-[2-(1,1-Dimethylethyl)-6-(trifluoromethyl)-4-pyrimidinyl]-1-piperazinyl]propyl]thio]-4(3H)-pyrimidinone; 2-[[3-[4-[2-(1,1-Dimethylethyl)-6-(trifluoromethyl)-4-pyrimidinyl]-1-piperazinyl]propyl]thio]-4(1H)-pyrimidinone
CAS Number:220519-06-2
Molecular Formula:C₂₀H₂₇F₃N₆OS
Appearance:Off-White Solid
Melting Point:133-138°C
Molecular Weight:456.53
Storage:-20°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A 37203 is a selective D3 receptor antagonist and intermediate in the synthesis of ABT 925 Fumerate (A112600), which is also a dopamine D3 receptor antagonist and used in the treatment of acute schizophrenia.
References:Redden, L., et al.: J. Clin. Psychopharmacol, 31, 221 (2011); Basso, A.M., et al.: Neuropsychopharmacology, 30, 1257 (2005)
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