CAS:1257044-40-8|ABT 199 (Venetoclax)

Catalogue Number:A112430
Chemical Name:ABT 199 (Venetoclax)
Synonyms:4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; Venetoclax
CAS Number:1257044-40-8
Molecular Formula:C₄₅H₅₀ClN₇O₇S
Appearance:Light Yellow to Yellow Solid
Melting Point:129-163ºC
Molecular Weight:868.44
Storage:-20°C
Solubility:Chloroform (Slightly, Heated), DMSO (Slightly, Heated)
Category:Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
References:Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);
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