CAS:1231929-97-7|Abemaciclib

Catalogue Number:A115153
Chemical Name:Abemaciclib
Synonyms:N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine; LY 2835219; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
CAS Number:1231929-97-7
Molecular Formula:C₂₇H₃₂F₂N₈
Appearance:Pale Yellow to Light Yellow Solid
Melting Point:175 – 178°C
Molecular Weight:506.59
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:Abemaciclib is a potent and selective inhibitor of cyclin-dependent kinases, CDK4 and CDK6, as a method to inhibit the proliferation of cancer cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:O’Leary, Ben., et al.: Nat Rev Clin Oncol.,  13, 417 (2016); Van Arsdale., et al.: Clin. Cancer Res., 21, 2905 (2015);
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