CAS:1809251-51-1|Abemaciclib-D5

Catalogue Number:A115154
Chemical Name:Abemaciclib-D5
Synonyms:N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine-d4; LY 2835219-d4; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine-d4
CAS Number:1809251-51-1
Molecular Formula:C₂₇H₂₇D₅F₂N₈
Molecular Weight:511.64
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:Isotope labelled Abemaciclib is a potent and selective inhibitor of cyclin-dependent kinases, CDK4 and CDK6, as a method to inhibit the proliferation of cancer cells.
References:O’Leary, Ben., et al.: Nat Rev Clin Oncol.,  13, 417 (2016); Van Arsdale., et al.: Clin. Cancer Res., 21, 2905 (2015);
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