CAS:1878175-77-9|[[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yloxy]methyl]phosphonic Acid Mono[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl] Ester

Catalogue Number:A123885
Chemical Name:[[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yloxy]methyl]phosphonic Acid Mono[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl] Ester
Synonyms:Mono[(1R)​-​2-​(6-​amino-​9H-​purin-​9-​yl)​-​1-​methylethyl] Ester P-​[[(1R)​-​2-​(6-Amino-​9H-​purin-​9-​yl)​-​1-​methylethoxy]​methyl]phosphonic Acid;
CAS Number:1878175-77-9
Molecular Formula:C₁₇H₂₃N₁₀O₄P
Appearance:White to Off-White Solid
Melting Point:178 – 181ºC
Molecular Weight:462.4
Storage:-20°C
Solubility:DMSO (Slightly), Water (Slightly)
Stability
Hygroscopic
Category:Building Blocks; Miscellaneous; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R)-Bis(1-methylethyl) Ester [[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid is a Tenofovir Disoproxil Fumarate (T018505) related compound which is an acyclic phosphonate nucleotide analogue
References:Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005); Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007); Chen, J., Faming Zhuanli Shenqing (2020), CN 110655535 A 20200107;
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