CAS:160616-04-6|(R)-Bis(1-methylethyl) Ester [[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid

Catalogue Number:A123895
Chemical Name:(R)-Bis(1-methylethyl) Ester [[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
Synonyms:Bis(1-methylethyl) P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonate; Bis(1-methylethyl) Ester [[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid; Diisopropyl [[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yloxy]methyl]phosphonate;
CAS Number:160616-04-6
Molecular Formula:C₁₅H₂₆N₅O₄P
Appearance:White to Off-White Solid
Melting Point:107 – 110 ºC
Molecular Weight:371.37
Storage:-20°C
Solubility:Chloroform (Slightly), DMF (Slightly), DMSO (Slightly), Water (Slightly)
Category:Building Blocks; Miscellaneous; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R)-Bis(1-methylethyl) Ester [[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid is a Tenofovir Disoproxil Fumarate (T018505) related compound which is an acyclic phosphonate nucleotide analogue
References:Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005); Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007); Havale, S. H., et al.: Indian Pat. Appl. (2017), IN 2015CH04214 A 20170217;
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