CAS:98966-17-7|N-​[5-​(Acetylamino)​-​2-​hydroxyphenyl]​-​N-​(4-​hydroxyphenyl)​acetamide

Catalogue Number:A161245
Chemical Name:N-​[5-​(Acetylamino)​-​2-​hydroxyphenyl]​-​N-​(4-​hydroxyphenyl)​acetamide
Synonyms:Acetaminophen Dimer Impurity; Paracetamol Dimer 3; Acetaminophen Impurity B
Impurity:Acetaminophen Impurity B
CAS Number:98966-17-7
Molecular Formula:C₁₆H₁₆N₂O₄
Appearance:Off-White to Pale Orange to Dark Brown Solid
Melting Point:141-145°C
Molecular Weight:300.31
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-​[5-​(Acetylamino)​-​2-​hydroxyphenyl]​-​N-​(4-​hydroxyphenyl)​acetamide is an impurity of Acetaminophen (A161220), which is an analgesic and antipyretic (1,2,3,4). N-​[5-​(Acetylamino)​-​2-​hydroxyphenyl]​-​N-​(4-​hydroxyphenyl)​acetamide may be a useful reagent to investigate mechanisms related to liver and kidney damage from acetaminophen. Acetaminophen Impurity B.
References:(1) Potter, D. W. and Hinson, J. A.: Drug Metab Rev. 20, 341 (1989)
(2) Potter, D. W. and Hinson, J. A.: J. Biol. Chem. 260, 12174 (1985)
(3) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)
(4) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)
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