CAS:6296-53-3|3-Acetylaminophthalic Anhydride

Catalogue Number:A170980
Chemical Name:3-Acetylaminophthalic Anhydride
Synonyms:3-Acetamidophthalic Anhydride; 3-Acetamidophthalic anhydride; NSC 16261; NSC 17048
Impurity:Apremilast Impurity 2
CAS Number:6296-53-3
Molecular Formula:C₁₀H₇NO₄
Appearance:Off-White to Pale Yellow Solid
Melting Point:184-186°C
Molecular Weight:205.17
Storage:-20°C, Hygroscopic
Solubility:Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly, Sonicated), Methanol
Stability
Moisture Sensitive
Category:Building Blocks; Miscellaneous;
Applications:3-Acetylaminophthalic Anhydride is used in the synthesis of Apremilast, a potent phosphodiesterase 4 and tumor necrosis Factor-a inhibitor used in the treatment of psoriatic arthritis. Also a reagent in the preparation of Tillivalline. Apremilast Impurity 2
References:Man, H. et al.: J. Med. Chem., 52, 1522 (2009); Nagasaka, T. et al.: J. Org. Chem., 63, 697 (1998);
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