CAS:185413-30-3|AF 12198

Catalogue Number:A355020
Chemical Name:AF 12198
CAS Number:185413-30-3
Molecular Formula:C₉₆H₁₂₃N₁₉O₂₂
Appearance:White to Off-White Solid
Melting Point:>179°C (dec.)
Molecular Weight:1895.12
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
Category:Standards; Amino Acids/Peptides;
Applications:N-​Acetyl-​L-​phenylalanyl-​L-​a-​glutamyl-​L-​tryptophyl-​L-​threonyl-​L-​prolylglycyl-​L-​tryptophyl-​L-​tyrosyl-​L-​glutaminyl-​(2S)​-​2-​azetidinecarbonyl-​L-​tyrosyl-​L-​alanyl-​L-​leucyl-​L-​prolyl-L-​Leucinamide is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders.
References:(1) Akeson, A., et al.: J. Biol. Chem. (1996) 271, 30517-23
(2) Yang, C. Y.: PLoS One (2015) 10:e0118671
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