CAS:2482-00-0|Agmatine Sulfate

Catalogue Number:A426900
Chemical Name:Agmatine Sulfate
Synonyms:N-(4-aminobutyl)guanidine Sulfate; NIH 11035
CAS Number:2482-00-0
Alternate CAS #
Free Base: 306-60-5
Molecular Formula:C₅H₁₆N₄O₄S
Appearance:White to Off-White Solid
Melting Point:231-233°C
Molecular Weight:228.27
Storage:20°C
Solubility:Water (Slightly, Heated)
Category:Standards; Amino Acids; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:General Uses: Neuroprotective, CNS studies, Autism and depression researchDescription:Agmatine Sulfate is a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine at a2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects. It blocks NMDA-receptor associated cation channels. Acts as a competitive inhibitor of nitric oxide synthase (NOS). It functions as neurotransmitter since it is stored in synaptic vesicles and is related from axon terminals by depolarization(1). Protects autistic behavior in rats (2) and reverses depressive like behavior in mice. (3)
References:Reis DJ, et al. 2000; Trends Pharmacol Sci. 2000 May;21(5):187-93
Kim JW, et al. 2016 Neuropharmacology. Sep 14;113(Pt A):71-81
Neis VB, et al. 2016 Pharmacol Biochem Behav. Oct 12;150-151:108-114
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