CAS:902779-59-3|Akt Inhibitor XI

Catalogue Number:A450500
Chemical Name:Akt Inhibitor XI
Synonyms:(SP-4-3)-Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide-κN2,κS]-copper; FPA-124
CAS Number:902779-59-3
Molecular Formula:C₁₁H₉Cl₂CuN₃O₂S
Appearance:Green Solid
Melting Point:>209°C (dec.)
Molecular Weight:381.73
Storage:4°C, Hygroscopic
Solubility:DMSO (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:Akt inhibitor XI inhibits Akt in various cancer cells. Protein kinase B (PKB or Akt) is a serene/threonine kinase, which is involved in a wide variety of cellular processes including metabolism, apoptosis and cell proliferation. Furthermore, Akt inhibitor XI was employed in a biological study that aimed to develop a novel coiled-coil three-hybrid system that can identify potential allosteric inhibitors.
References:Dan, S., et al.: Cancer Res. 70, 4982 (2010); Jester, B. W., et al.: J. Am. Chem. Soc. 132, 11727 (2010); Jester, B. W., et al.: J. Med. Chem. 55, 1526 (2012); Fedichev, P. O. and Vinnik, A. A. PCT Int. Appl. WO 2013147649 A2 20131003 (2013)
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