CAS:516-54-1|(3a)-Allopregnanolone

Catalogue Number:A547100
Chemical Name:(3a)-Allopregnanolone
Synonyms:(+)-3?-Hydroxy-5?-pregnan-20-one; (3?,5?)-3-Hydroxypregnan-20-one; 3?,5?-THP; 3?,5?-Tetrahydroprogesterone; 3?-Hydroxy-5?-dihydroprogesterone; 3?-Hydroxy-5?-pregnan-20-one; 3?-Hydroxy-5?-pregnane-20-one; 5?-Pregnan-3?-ol-20-one; 5?-Pregnane-3?-ol-20-one; Allopregnan-3?-ol-20-one; Allopregnanolone; Allotetrahydroprogesterone;
CAS Number:516-54-1
Molecular Formula:C₂₁H₃₄O₂
Appearance:White to Off-White Solid
Melting Point:174-175C
Molecular Weight:318.49
Storage:4°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Steroids; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(3?)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3?)-Allopregnanolone is a metabolite of Progesterone (P755900). (3?)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain. In 2019, the US Food and Drug Administration approved (3?)-Allopregnanolone as an intravenous infusion for treating postpartum depression.
References:Puja, G. et al.: Neuron, 4, 759 (1990); Belelli, D. et ael. Neurosteroid, 6, 565 (2006); Viapiano, M. et al.: Neurochem. Res., 23, 155 (1998);
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