CAS:1027847-67-1|4-[4-[(Butylamino)carbonyl]-2-[[(2,4-dichlorophenyl)sulfonyl]amino]phenoxy]-3-methoxy-benzeneacetic Acid

Catalogue Number:A576555
Chemical Name:4-[4-[(Butylamino)carbonyl]-2-[[(2,4-dichlorophenyl)sulfonyl]amino]phenoxy]-3-methoxy-benzeneacetic Acid
Synonyms:AMG 009;
CAS Number:1027847-67-1
Molecular Formula:C₂₆H₂₆Cl₂N₂O₇S
Appearance:Pale Brown Solid
Melting Point:144-149°C
Molecular Weight:581.46
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:4-[4-[(Butylamino)carbonyl]-2-[[(2,4-dichlorophenyl)sulfonyl]amino]phenoxy]-3-methoxy-benzeneacetic Acid is a dual prostanoid D receptor (DP) and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. DP and CRTH2 are involved in mediating allergic reactions (asthma, allergic rhinitis, and atopic dermatitis). Compounds that inhibit these receptors may hold potential for treating allergic diseases.
References:Liu, J., et al.: Bioorg. Med. Chem. Lett. 19, 6419 (2009); Liu, J., et al.: ACS Med Chem Lett. 2, 326 (2011)
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