(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic Acid

Chemical Name:(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic Acid
Synonyms:(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid;
CAS Number:1135695-98-5
Molecular Formula:C₂₆H₂₅F₂N₃O₆
Molecular Weight:513.49
Category:Standards; Enzyme Activators and Inhibitors;
Applications:An inhibitor that is used in Alzheimer’s studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor.
References:Mintzer, R. et al.: PLoS One, 7, 30376 (2012); Pierre L.B. et al.: J. Org. Chem., 62, (3440 (1997)
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